Dichloromethane → HCID 58117796, compound

HRID 405937Notes

Reaction equation

HRID 405937 reaction equation
FC(F)(F)C([N:5]1[CH2:11][CH2:10][C:9]2[CH:12]=[C:13]([O:16][CH:17]3[CH2:22][CH2:21][N:20]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:19][CH2:18]3)[CH:14]=[CH:15][C:8]=2[CH2:7][CH2:6]1)=O.C(=O)([O-])[O-].[K+].[K+].ClCCl>CO.O>[CH2:7]1[C:8]2[CH:15]=[CH:14][C:13]([O:16][CH:17]3[CH2:18][CH2:19][N:20]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:21][CH2:22]3)=[CH:12][C:9]=2[CH2:10][CH2:11][NH:5][CH2:6]1

Participants

6

Reactant 3

HCID 6344DichloromethaneHCID 11430Potassium CarbonateHCID 58117728HCID 58117728, compound

Product 1

HCID 58117796HCID 58117796, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 962WaterSolvent2×

Procedure

400 mg tert-butyl 4-[3-(2,2,2-trifluoracetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yloxy]-piperidine-1-carboxylate (see 38.2) are placed in 17 ml of methanol, then a mixture of 151.2 mg potassium carbonate in 3.3 ml of water is added. The reaction mixture is stirred at ambient temperature, until there is no further reaction. The methanol is then spun off. The residue is combined with dichloromethane and water. The organic phase is dried and evaporated to dryness. 310 mg are obtained as an oil.

Workup

  1. additionis added
  2. customno further reaction
  3. customThe organic phase is dried
  4. customevaporated to dryness
  5. custom310 mg are obtained as an oil

Sources & evidence

ORD record
ord-dd2cda13f2b1460b92682dd5ef1ca6d9
Source dataset
uspto-grants-2014_06
Patent number
US08754073B2

Reaction notes

Loading…