Trifluoroacetic acid → HCID 58117943, compound

HRID 405939Notes

Reaction equation

HRID 405939 reaction equation
[CH:1]1([C:4]([N:6]2[CH2:12][CH2:11][C:10]3[CH:13]=[C:14]([O:17][CH:18]4[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]4)[CH:15]=[CH:16][C:9]=3[CH2:8][CH2:7]2)=[O:5])[CH2:3][CH2:2]1.FC(F)(F)C(O)=O>ClCCl>[CH:1]1([C:4]([N:6]2[CH2:12][CH2:11][C:10]3[CH:13]=[C:14]([O:17][CH:18]4[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]4)[CH:15]=[CH:16][C:9]=3[CH2:8][CH2:7]2)=[O:5])[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58117700HCID 58117700, compound

Product 1

HCID 58117943HCID 58117943, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

70 mg tert-butyl 4-(3-cyclopropanecarbonyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yloxy)-piperidine-1-carboxylate are placed in 1.4 ml dichloromethane and combined with 224 l trifluoroacetic acid. The reaction mixture is stirred for 3 hours at ambient temperature, then evaporated to dryness. The residue is combined with toluene and evaporated to dryness. 77 mg (V-18) are obtained as an oil. Analytical HPLC-MS (method B): RT=1.18 min.

Workup

  1. customevaporated to dryness
  2. customevaporated to dryness
  3. custom77 mg (V-18) are obtained as an oil

Sources & evidence

ORD record
ord-e291b92147484981963596692fe3a393
Source dataset
uspto-grants-2014_06
Patent number
US08754073B2

Reaction notes

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