Trifluoroacetic acid → HCID 58080362, compound

HRID 405947Notes

Reaction equation

HRID 405947 reaction equation
[C:1]1([C:7]2[N:8]=[C:9]([CH:18]3[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]3)[O:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.FC(F)(F)C(O)=O>ClCCl>[C:1]1([C:7]2[N:8]=[C:9]([CH:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[O:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58080370HCID 58080370, compound

Product 1

HCID 58080362HCID 58080362, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

560 mg tert-butyl 4-(4,5-diphenyloxazol-2-yl)-piperidine-1-carboxylate are placed in 2 ml dichloromethane, then 1.1 ml trifluoroacetic acid are added. The reaction mixture is stirred for 15 hours at ambient temperature, then evaporated to dryness. The residue is combined with toluene and evaporated to dryness again. The residue is combined with diethyl ether and the precipitated solid is suction filtered and dried. 510 mg (V-26) are obtained.

Workup

  1. customevaporated to dryness
  2. customevaporated to dryness again
  3. filtrationfiltered
  4. customdried
  5. custom510 mg (V-26) are obtained

Sources & evidence

ORD record
ord-99134db5c93841acbd20e5032947acb7
Source dataset
uspto-grants-2014_06
Patent number
US08754073B2

Reaction notes

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