2-Chlorocyclohexanone → HCID 58080363, compound

HRID 405949Notes

Reaction equation

HRID 405949 reaction equation
Cl[CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C:3]1=[O:8].[CH2:9]([N:16]1[CH2:21][CH2:20][CH:19]([C:22]([NH2:24])=O)[CH2:18][CH2:17]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[CH2:9]([N:16]1[CH2:21][CH2:20][CH:19]([C:22]2[O:8][C:3]3[CH2:4][CH2:5][CH2:6][CH2:7][C:2]=3[N:24]=2)[CH2:18][CH2:17]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 132032-ChlorocyclohexanoneHCID 7831561-Benzylpiperidine-4-carboxamide

Product 1

HCID 58080363HCID 58080363, compoundYield 70.9%

Conditions

Temperature
160 °C

Procedure

A mixture of 2.43 g 2-chlorocyclohexanone and 1 g 1-benzylpiperidine-4-carboxylic acid amide (see WO2005/61483) is heated to 160° C. in the microwave until there is no further reaction. The product is purified by chromatography. 963 mg of the product are obtained. Analytical HPLC-MS (method B): RT=1.28 min.

Workup

  1. customno further reaction
  2. customThe product is purified by chromatography

Sources & evidence

ORD record
ord-73e7b1ec42b9406591b076b0e4066ea6
Source dataset
uspto-grants-2014_06
Patent number
US08754073B2

Reaction notes

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