Sodium Hydroxide → HCID 67382325, compound

HRID 406006Notes

Reaction equation

HRID 406006 reaction equation
C([Si](C)(C)[O:6][C@H:7]1[CH2:12][CH2:11][CH2:10][C@H:9]([O:13][C:14]2[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=2[NH2:21])[CH2:8]1)(C)(C)C.[OH-].[Na+]>Cl.C(O)C>[NH2:21][C:15]1[CH:16]=[CH:17][C:18]([F:20])=[CH:19][C:14]=1[O:13][C@H:9]1[CH2:10][CH2:11][CH2:12][C@H:7]([OH:6])[CH2:8]1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 67390370HCID 67390370, compound

Product 1

HCID 67382325HCID 67382325, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolvent

Procedure

A solution of 8.1 g 2-[trans-3-(tert-butyl-dimethyl-silanyloxy)-cyclohexyloxy]-4-fluoro-phenylamine in 50 ml of HCl in ethanol (1.25 M) was stirred for 1 hour at rt. Sodium hydroxide solution (1 N) was then added to the reaction mixture resulting in a basic pH. This mixture was extracted with methylene chloride. The organic phase was dried over sodium sulfate, filtered and concentrated.

Workup

  1. customresulting in a basic pH
  2. extractionThis mixture was extracted with methylene chloride
  3. dry with materialThe organic phase was dried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-d16f0df4eabd44c881c45b5568144c4b
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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