Hydrochloric Acid → HCID 178479276, compound

HRID 406009Notes

Reaction equation

HRID 406009 reaction equation
[ClH:1].C(OC(=O)[NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([O:15][C:16]2[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:17]=2[N+:23]([O-:25])=[O:24])[CH2:11][CH2:10]1)(C)(C)C>O1CCOCC1.C(Cl)Cl>[ClH:1].[F:22][C:20]1[CH:19]=[CH:18][C:17]([N+:23]([O-:25])=[O:24])=[C:16]([CH:21]=1)[O:15][C@H:12]1[CH2:11][CH2:10][C@H:9]([NH2:8])[CH2:14][CH2:13]1

Participants

5

Reactant 2

HCID 313Hydrochloric Acid2×HCID 178454067HCID 178454067, compound

Product 1

HCID 178479276HCID 178479276, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent2×

Procedure

10 ml of a solution of HCl in dioxane (4 M) were added to 1.19 g trans-[4-(5-fluoro-2-nitro-phenoxy)-cyclohexyl]-carbamic acid tert-butyl ester in methylene chloride. The mixture is stirred for 3 hours and 2 ml of HCl in dioxane (4 M) were added. The reaction mixture was stirred for 1 hour and concentrated in vacuo.

Workup

  1. stirringThe reaction mixture was stirred for 1 hour
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-3d2c139bc0294a8286b4877ec3b4197f
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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