Triethylamine → HCID 178523801, compound

HRID 406018Notes

Reaction equation

HRID 406018 reaction equation
Cl.[F:2][C:3]1[CH:4]=[CH:5][C:6]([N+:17]([O-:19])=[O:18])=[C:7]([CH:16]=1)[O:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([NH2:15])[CH2:11][CH2:10]1.C([O:22][C:23](=O)[C:24]([F:27])([F:26])[F:25])C.C(N(CC)CC)C>CO>[N+:17]([C:6]1[CH:5]=[CH:4][C:3]([F:2])=[CH:16][C:7]=1[O:8][C@H:9]1[CH2:10][CH2:11][C@H:12]([NH:15][C:23](=[O:22])[C:24]([F:27])([F:26])[F:25])[CH2:13][CH2:14]1)([O-:19])=[O:18]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 9794Ethyl trifluoroacetateHCID 178479276HCID 178479276, compound

Product 1

HCID 178523801HCID 178523801, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A reaction mixture of 0.071 g trans-4-(5-fluoro-2-nitro-phenoxy)-cyclohexylamine hydrochlorid, 0.05 g ethyltrifluoroacetate and 0.075 g triethylamine in 2 ml methanol was stirred overnight. The mixture was concentrated and partitioned between 5 ml EtOAc and 5 ml water. The organic phase was washed with water, HCl solution (2M) and water. The organic phase was dried and the solvent evaporated.

Workup

  1. concentrationThe mixture was concentrated
  2. custompartitioned between 5 ml EtOAc and 5 ml water
  3. washThe organic phase was washed with water, HCl solution (2M) and water
  4. customThe organic phase was dried
  5. customthe solvent evaporated

Sources & evidence

ORD record
ord-e4909198e944432f99053f078232ef51
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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