Water → HCID 58421737, compound

HRID 406021Notes

Reaction equation

HRID 406021 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([O:11][C@@H:12]2[CH2:17][CH2:16][CH2:15][CH2:14][C@H:13]2[OH:18])[CH:3]=1.F[B-](F)(F)F.[CH3:24][O+](C)C.O>C(Cl)Cl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([O:11][C@@H:12]2[CH2:17][CH2:16][CH2:15][CH2:14][C@H:13]2[O:18][CH3:24])[CH:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 2735153Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1)HCID 58421658HCID 58421658, compound

Product 1

HCID 58421737HCID 58421737, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To (R,R)-4-fluoro-2-(2-hydroxycyclohexyloxy)-nitrobenzene (0.200 g) dissolved in methylene chloride (10.0 ml) was added trimethyloxonium tetrafluoroborate (0.348 g). The mixture was stirred overnight at rt. Water was added; the organic phase was separated and evaporated to dryness to yield a brownish oil.

Workup

  1. customthe organic phase was separated
  2. customevaporated to dryness
  3. customto yield a brownish oil

Sources & evidence

ORD record
ord-0d45a76fa01740f6964b6bf8a00ae1e0
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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