HCID 58421658, compound → HCID 58421525, compound

HRID 406023Notes

Reaction equation

HRID 406023 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[C:4]([O:11][C@@H:12]2[CH2:17][CH2:16][CH2:15][CH2:14][C@H:13]2[OH:18])[CH:3]=1.[H][H]>CO.[Pd]>[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([O:11][C@@H:12]2[CH2:17][CH2:16][CH2:15][CH2:14][C@H:13]2[OH:18])[CH:3]=1

Participants

5

Reactant 2

HCID 58421658HCID 58421658, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 58421525HCID 58421525, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

(R,R)-4-Fluoro-2-(2-hydroxycyclohexyloxy)-nitrobenzene (1.99 g) in methanol (20.0 ml) was hydrogenated under 50 psi hydrogen for 5 h at rt using palladium on charcoal (5%) (200 mg) as catalyst. The catalyst was filtered off; the resulting solution was evaporated to dryness to yield an oil.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe resulting solution was evaporated to dryness
  3. customto yield an oil

Sources & evidence

ORD record
ord-73a3a7e12e3f4ce19c79fca9d88584d2
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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