Acetyl chloride → HCID 178475047, compound

HRID 406036Notes

Reaction equation

HRID 406036 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[F:5][C:6]([F:11])([F:10])[C:7]([OH:9])=[O:8].[F:12][C:13]1[CH:14]=[CH:15][C:16]([N+:25]([O-:27])=[O:26])=[C:17]([CH:24]=1)[O:18][C@H:19]1[CH2:22][C@H:21]([NH2:23])[CH2:20]1.C(N(CC)CC)C>C(Cl)Cl>[F:5][C:6]([F:11])([F:10])[C:7]([OH:9])=[O:8].[F:12][C:13]1[CH:14]=[CH:15][C:16]([N+:25]([O-:27])=[O:26])=[C:17]([CH:24]=1)[O:18][C@H:19]1[CH2:20][C@H:21]([NH:23][C:1](=[O:3])[CH3:2])[CH2:22]1

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 178511743HCID 178511743, compound

Product 1

HCID 178475047HCID 178475047, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

450 μl Acetylchloride were added to a mixture of 1.8 g trans-3-(5-fluoro-2-nitrophenoxy)-cyclobutylamine trifluoroacetate and 3.7 ml triethylamine in 30 ml methylene chloride and stirred for 2 hours at rt. The mixture was extracted two times with water. The organic phase was dried and concentrated. The residue was stirred with diethylether and filtrated. The residue was dried in a drying cabinet.

Workup

  1. extractionThe mixture was extracted two times with water
  2. customThe organic phase was dried
  3. concentrationconcentrated
  4. stirringThe residue was stirred with diethylether
  5. filtrationfiltrated
  6. customThe residue was dried in a drying cabinet

Sources & evidence

ORD record
ord-26c5a6c5daab449db29b408c1d134d7e
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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