反应详情

450 μl Acetylchloride were added to a mixture of 1.8 g trans-3-(5-fluoro-2-nitrophenoxy)-cyclobutylamine trifluoroacetate and 3.7 ml triethylamine in 30 ml methylene chloride and stirred for 2 hours at rt. The mixture was extracted two times with water. The organic phase was dried and concentrated. The residue was stirred with diethylether and filtrated. The residue was dried in a drying cabinet.

1. extractionThe mixture was extracted two times with water
2. customThe organic phase was dried
3. concentrationconcentrated
4. stirringThe residue was stirred with diethylether
5. filtrationfiltrated
6. customThe residue was dried in a drying cabinet