2,4-Difluoronitrobenzene → 4-Fluoro-2-((1S,2S)-2-methoxy-cyclohexyloxy)-1-nitro-benzene

HRID 406043Notes

Reaction equation

HRID 406043 reaction equation
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[CH3:12][O:13][C@H:14]1[CH2:19][CH2:18][CH2:17][CH2:16][C@@H:15]1[OH:20]>>[F:8][C:6]1[CH:5]=[CH:4][C:3]([N+:9]([O-:11])=[O:10])=[C:2]([O:20][C@H:15]2[CH2:16][CH2:17][CH2:18][CH2:19][C@@H:14]2[O:13][CH3:12])[CH:7]=1

Participants

3

Reactant 2

HCID 679672,4-DifluoronitrobenzeneHCID 10197706(1S,2S)-2-Methoxycyclohexanol

Product 1

HCID 584215384-Fluoro-2-((1S,2S)-2-methoxy-cyclohexyloxy)-1-nitro-benzene

Procedure

Prepared analogously to III.1 from 926 μl 2,4-difluor-nitrobenzene and 1 g (1S,2S)-2-methoxycyclohexanol.

Sources & evidence

ORD record
ord-18e7107c71734a4ebc8cb6a18c00d973
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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