m-Chloroperbenzoic acid → HCID 58421606, compound

HRID 406054Notes

Reaction equation

HRID 406054 reaction equation
[CH:1]1([O:6][C:7]2[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:8]=2[N+:14]([O-:16])=[O:15])[CH2:5][CH:4]=[CH:3][CH2:2]1.ClC1C=C(C=CC=1)C(OO)=[O:22]>C(Cl)Cl>[F:13][C:11]1[CH:10]=[CH:9][C:8]([N+:14]([O-:16])=[O:15])=[C:7]([CH:12]=1)[O:6][CH:1]1[CH2:5][CH:4]2[CH:3]([O:22]2)[CH2:2]1

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 58421507HCID 58421507, compound

Product 1

HCID 58421606HCID 58421606, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To 2-(cyclopent-3-enyloxy)-4-fluoro-1-nitrobenzene (2.05 g) in methylene chloride (45.0 ml) at 0° C. was added 3-chloroperoxybenzoic acid (2.95 g) and the mixture was allowed to warm to room temperature overnight. The reaction mixture was diluted with methylene chloride and washed with 10% aq. K2CO3. The organic layer was passed through a hydrophobic frit and solvent evaporated to give the desired product.

Workup

  1. washwashed with 10% aq. K2CO3
  2. customevaporated

Sources & evidence

ORD record
ord-2a051d69465c43d6956b0f67af68d44d
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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