Trifluoroacetic acid → HCID 67382670, compound

HRID 406055Notes

Reaction equation

HRID 406055 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:12][CH2:11][C@H:10]([O:13][C:14]2[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=2[N+:21]([O-:23])=[O:22])[CH2:9]1)(C)(C)C.[C:25]([OH:31])([C:27]([F:30])([F:29])[F:28])=[O:26]>C(Cl)Cl>[F:28][C:27]([F:30])([F:29])[C:25]([OH:31])=[O:26].[F:20][C:18]1[CH:17]=[CH:16][C:15]([N+:21]([O-:23])=[O:22])=[C:14]([CH:19]=1)[O:13][C@H:10]1[CH2:11][CH2:12][C@H:8]([NH2:7])[CH2:9]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58421651HCID 58421651, compound

Product 1

HCID 67382670HCID 67382670, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To [(1S,3S)-3-(5-fluoro-2-nitro-phenoxy)-cyclopentyl]-carbamic acid tert-butyl ester, cpd. XXXVII.1 (2.13 g) in DCM (150 ml) was added at 0° C. TFA (10 ml) and stirred at rt overnight. The reaction mixture was concentrated at rt and triturated with diisopropyl ether to give the desired compound.

Workup

  1. concentrationThe reaction mixture was concentrated at rt
  2. customtriturated with diisopropyl ether

Sources & evidence

ORD record
ord-37aa4f09131b4e2e9999d2106f76d7a1
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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