Hydrochloric Acid → HCID 58421739, compound

HRID 406060Notes

Reaction equation

HRID 406060 reaction equation
C[O:2][C:3]([C:5]1[S:35][C:8]2[N:9]=[CH:10][N:11]=[C:12]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=3[O:21][C@H:22]3[CH2:26][CH2:25][CH2:24][C@@H:23]3[NH:27][C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[C:7]=2[C:6]=1[CH3:36])=[O:4].[OH-].[Na+].Cl>CO.O>[C:31]([O:30][C:28]([NH:27][C@H:23]1[CH2:24][CH2:25][CH2:26][C@@H:22]1[O:21][C:15]1[CH:16]=[C:17]([F:20])[CH:18]=[CH:19][C:14]=1[NH:13][C:12]1[C:7]2[C:6]([CH3:36])=[C:5]([C:3]([OH:4])=[O:2])[S:35][C:8]=2[N:9]=[CH:10][N:11]=1)=[O:29])([CH3:34])([CH3:32])[CH3:33]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 58421576HCID 58421576, compound

Product 1

HCID 58421739HCID 58421739, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A mixture of 2.4 g (1S,2S) 4-[2-(2-tert-butoxycarbonylamino-cyclopentyloxy)-4-fluoro-phenylamino]-5-methyl thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester and 20 ml 1M sodium hydroxide solution in 50 ml MeOH was stirred at rt overnight. To the reaction mixture was added 20 ml 1M hydrochloric acid until a pH range of 2-3 was reached. The mixture was diluted with water and filtrated. The solid was dried in vacuo at 50° C.

Workup

  1. filtrationfiltrated
  2. customThe solid was dried in vacuo at 50° C.

Sources & evidence

ORD record
ord-0e034265de37469e9188ffcbc2222d58
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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