HCID 178428775, compound → HCID 178484837, compound

HRID 406063Notes

Reaction equation

HRID 406063 reaction equation
C(O[C:6](=O)[N:7]([C@H:9]1[CH2:14][CH2:13][C@H:12]([O:15][C:16]2[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:17]=2[NH:23][C:24]2[C:25]3[C:32]([CH3:33])=[C:31]([C:34](=[O:36])[NH2:35])[S:30][C:26]=3[N:27]=[CH:28][N:29]=2)[CH2:11][CH2:10]1)C)(C)(C)C>Cl.O1CCOCC1.CO>[F:22][C:20]1[CH:19]=[CH:18][C:17]([NH:23][C:24]2[C:25]3[C:32]([CH3:33])=[C:31]([C:34]([NH2:35])=[O:36])[S:30][C:26]=3[N:27]=[CH:28][N:29]=2)=[C:16]([O:15][C@H:12]2[CH2:13][CH2:14][C@H:9]([NH:7][CH3:6])[CH2:10][CH2:11]2)[CH:21]=1

Participants

4

Reactant 1

HCID 178428775HCID 178428775, compound

Product 1

HCID 178484837HCID 178484837, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

A mixture of 0.684 g tert-butyl-trans-4-(−2-(6-carbamoyl-5-methylthieno[2,3-d]pyrimidin-4-ylamino)-5-fluorophenoxy)cyclohexyl(methyl)carbamate in 5 ml 4 M HCl/dioxane and 5 ml MeOH was stirred at rt for 1.5 h. The reaction mixture was concentrated in vacuo. The crude was purified by chromatography to give the desired product.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customThe crude was purified by chromatography

Sources & evidence

ORD record
ord-7ff3f8a2ea63463d86df7ce229d6f65c
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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