HCID 178428775, compound → HCID 178484837, compound

Participants

Reaction Steps

A mixture of 0.684 g tert-butyl-trans-4-(−2-(6-carbamoyl-5-methylthieno[2,3-d]pyrimidin-4-ylamino)-5-fluorophenoxy)cyclohexyl(methyl)carbamate in 5 ml 4 M HCl/dioxane and 5 ml MeOH was stirred at rt for 1.5 h. The reaction mixture was concentrated in vacuo. The crude was purified by chromatography to give the desired product.

Provenance & Evidence