Hydrochloric Acid → HCID 178475046, compound

HRID 406073Notes

Reaction equation

HRID 406073 reaction equation
C[O:2][C:3]([C:5]1[S:30][C:8]2[N:9]=[CH:10][N:11]=[C:12]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=3[O:21][C@H:22]3[CH2:25][C@H:24]([NH:26][C:27](=[O:29])[CH3:28])[CH2:23]3)[C:7]=2[C:6]=1[CH3:31])=[O:4].Cl>[OH-].[Na+].CO>[C:27]([NH:26][C@H:24]1[CH2:25][C@H:22]([O:21][C:15]2[CH:16]=[C:17]([F:20])[CH:18]=[CH:19][C:14]=2[NH:13][C:12]2[C:7]3[C:6]([CH3:31])=[C:5]([C:3]([OH:4])=[O:2])[S:30][C:8]=3[N:9]=[CH:10][N:11]=2)[CH2:23]1)(=[O:29])[CH3:28]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178499246HCID 178499246, compound

Product 1

HCID 178475046HCID 178475046, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A mixture of 1.800 g 4-[2-(trans-3-acetylamino-cyclobutoxy)-4-fluoro-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester (cpd.35.1) in 17 ml sodium hydroxide solution (1M) and 30 ml MeOH was stirred at rt overnight. The reaction mixture was neutralized with aq. HCl (1M) and concentrated. The residue was filtered and the filtercake was washed with diethyl ether.

Workup

  1. concentrationconcentrated
  2. filtrationThe residue was filtered
  3. washthe filtercake was washed with diethyl ether

Sources & evidence

ORD record
ord-c364df3ddd6a4f73ab8e78260b8e0c95
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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