Hydrochloric Acid → HCID 58421769, compound

HRID 406077Notes

Reaction equation

HRID 406077 reaction equation
[OH-].[Na+].C[O:4][C:5]([C:7]1[S:31][C:10]2[N:11]=[CH:12][N:13]=[C:14]([NH:15][C:16]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=3[O:23][C@H:24]3[CH2:29][CH2:28][CH2:27][CH2:26][C@@H:25]3[OH:30])[C:9]=2[C:8]=1[CH3:32])=[O:6].Cl>CO.C1COCC1.O>[F:22][C:19]1[CH:20]=[CH:21][C:16]([NH:15][C:14]2[C:9]3[C:8]([CH3:32])=[C:7]([C:5]([OH:6])=[O:4])[S:31][C:10]=3[N:11]=[CH:12][N:13]=2)=[C:17]([O:23][C@H:24]2[CH2:29][CH2:28][CH2:27][CH2:26][C@@H:25]2[OH:30])[CH:18]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 58421787HCID 58421787, compound

Product 1

HCID 58421769HCID 58421769, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 21899815MeOH tetrahydrofuranSolvent

Procedure

5 ml sodium hydroxide solution (4M) was added to a mixture of 2.960 g 4-[4-Fluoro-2-((1S,2S)-2-hydroxy-cyclohexyloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester (cpd. 51.1) in 60 ml methanol/THF (1:1). The reaction mixture was stirred at rt for 3 hours, then acidified with aq. HCl and diluted with water. The mixture was filtered and the filtercake was dried.

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtercake was dried

Sources & evidence

ORD record
ord-3bd99942184a4e1db93f2fd55bf0ab72
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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