Triphenylphosphine → HCID 178499249, compound

HRID 406095Notes

Reaction equation

HRID 406095 reaction equation
[CH3:1][O:2][C:3]([C:5]1[S:21][C:8]2[N:9]=[CH:10][N:11]=[C:12]([NH:13][C:14]3[C:15]([OH:20])=[N:16][CH:17]=[CH:18][CH:19]=3)[C:7]=2[C:6]=1[CH3:22])=[O:4].[CH3:23][O:24][C@@H:25]1[CH2:30][CH2:29][C@H:28](O)[CH2:27][CH2:26]1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>>[CH3:1][O:2][C:3]([C:5]1[S:21][C:8]2[N:9]=[CH:10][N:11]=[C:12]([NH:13][C:14]3[C:15]([O:20][C@H:28]4[CH2:29][CH2:30][C@H:25]([O:24][CH3:23])[CH2:26][CH2:27]4)=[N:16][CH:17]=[CH:18][CH:19]=3)[C:7]=2[C:6]=1[CH3:22])=[O:4]

Participants

4

Reactant 3

HCID 11776TriphenylphosphineHCID 178496630HCID 178496630, compoundHCID 178499247HCID 178499247, compound

Product 1

HCID 178499249HCID 178499249, compound

Procedure

Prepared analogously to example XVI.1 from 1.215 g 4-(2-hydroxy-pyridin-3-ylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester and 0.6 g cis-4-methoxycyclohexanol using DTAD and triphenylphosphine (polymerically bound from Aldrich).

Sources & evidence

ORD record
ord-4eb45f6e72d946469fd7dce5e8726f52
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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