Hydrochloric Acid → 4-(5-Bromo-2-hydroxy-3-methoxy-benzyl)-piperazine-1-carboxylic acid phenylamide hydrochloride

HRID 40611Notes

Reaction equation

HRID 40611 reaction equation
[C:1]1([NH:7][C:8]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][C:17]3[CH:22]=[C:21]([Br:23])[CH:20]=[C:19]([O:24][CH3:25])[C:18]=3[OH:26])[CH2:12][CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:27]>CCOCC>[ClH:27].[C:1]1([NH:7][C:8]([N:10]2[CH2:15][CH2:14][N:13]([CH2:16][C:17]3[CH:22]=[C:21]([Br:23])[CH:20]=[C:19]([O:24][CH3:25])[C:18]=3[OH:26])[CH2:12][CH2:11]2)=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11596932HCID 11596932, compound

Product 1

HCID 687099564-(5-Bromo-2-hydroxy-3-methoxy-benzyl)-piperazine-1-carboxylic acid phenylamide hydrochloride

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a solution of 4-(5-bromo-2-hydroxy-3-methoxy-benzyl)-piperazine-1-carboxylic acid phenylamide (1.2 g) in Et2O (16 mL) was added HCl (2 M in Et2O, 3.5 mL). After 1 h, the mixture was concentrated to give the title compound as a white solid. 1H NMR (400 MHz, CD3OD): 7.40-7.20 (m, 6H), 7.10-7.05 (m, 1H), 4.37 (s, 2H), 3.94 (s, 3H).

Workup

  1. concentrationthe mixture was concentrated

Sources & evidence

ORD record
ord-8aabb1d109f74aa890cbb077c70e7bf6
Source dataset
uspto-grants-2013_09
Patent number
US08530476B2

Reaction notes

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