Hydrochloric Acid → HCID 58421471, compound

HRID 406115Notes

Reaction equation

HRID 406115 reaction equation
C[O:2][C:3]([C:5]1[S:28][C:8]2[N:9]=[CH:10][N:11]=[C:12]([NH:13][C:14]3[C:15]([O:20][CH:21]4[CH2:26][CH2:25][CH:24]([NH2:27])[CH2:23][CH2:22]4)=[N:16][CH:17]=[CH:18][CH:19]=3)[C:7]=2[C:6]=1[CH3:29])=[O:4].[OH-].[Na+].Cl>CO>[NH2:27][CH:24]1[CH2:25][CH2:26][CH:21]([O:20][C:15]2[C:14]([NH:13][C:12]3[C:7]4[C:6]([CH3:29])=[C:5]([C:3]([OH:4])=[O:2])[S:28][C:8]=4[N:9]=[CH:10][N:11]=3)=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:22][CH2:23]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 58421730HCID 58421730, compound

Product 1

HCID 58421471HCID 58421471, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
70 °C

Procedure

A mixture of 0.05 g 4-[2-(4-amino-cyclohexyloxy)-pyridin-3-ylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester and 1M sodium hydroxide solution in 5 ml MeOH was stirred at 70° C. for 1 hour. The reaction mixture was neutralized with 1M hydrochloric acid and concentrated. The residue was dissolved in DCM and MeOH, dried and filtered. The filtrate was concentrated. The residue was triturated with diethylether.

Workup

  1. concentrationconcentrated
  2. dissolutionThe residue was dissolved in DCM
  3. dry with materialMeOH, dried
  4. filtrationfiltered
  5. concentrationThe filtrate was concentrated
  6. customThe residue was triturated with diethylether

Sources & evidence

ORD record
ord-0e9b0c6c0c6e41839dbf7f524253d65e
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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