Dichloromethane → HCID 58421509, compound

HRID 406120Notes

Reaction equation

HRID 406120 reaction equation
[NH2:1][C@H:2]1[CH2:6][CH2:5][CH2:4][C@@H:3]1[O:7][C:8]1[CH:13]=[C:12]([F:14])[CH:11]=[CH:10][C:9]=1[NH:15][C:16]1[C:17]2[C:24]([CH3:25])=[C:23]([C:26]([NH2:28])=[O:27])[S:22][C:18]=2[N:19]=[CH:20][N:21]=1.C(N(CC)C(C)C)(C)C.C(Cl)Cl.[C:41](Cl)(=[O:43])[CH3:42]>O>[C:41]([NH:1][C@H:2]1[CH2:6][CH2:5][CH2:4][C@@H:3]1[O:7][C:8]1[CH:13]=[C:12]([F:14])[CH:11]=[CH:10][C:9]=1[NH:15][C:16]1[C:17]2[C:24]([CH3:25])=[C:23]([C:26]([NH2:28])=[O:27])[S:22][C:18]=2[N:19]=[CH:20][N:21]=1)(=[O:43])[CH3:42]

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 6367Acetyl chlorideHCID 81531DiisopropylethylamineHCID 58421738HCID 58421738, compound

Product 1

HCID 58421509HCID 58421509, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.15 g (1S,2S) 4-[2-(2-amino-cyclopentyloxy)-4-fluoro-phenylamino]-5-methyl thieno[2,3-d]pyrimidine-6-carboxylic acid amide and 0.32 ml N,N-diisopropylethylamine were mixed with DCM. 0.027 g acetylchloride were added to the mixture and stirred for 1 hour at rt. Then the reaction mixture was diluted with water and filtrated. The solid was air-dried.

Workup

  1. filtrationfiltrated
  2. customThe solid was air-dried

Sources & evidence

ORD record
ord-68ea3b0cada94b82a1eeb5d516d58a7c
Source dataset
uspto-grants-2014_06
Patent number
US08754079B2

Reaction notes

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