4-Bromo-2-methylbenzoic acid → HCID 67479574, compound

HRID 406124Notes

Reaction equation

HRID 406124 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([NH2:7])[CH2:3][CH2:2]1.[Br:8][C:9]1[CH:17]=[CH:16][C:12]([C:13](O)=[O:14])=[C:11]([CH3:18])[CH:10]=1>>[Br:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([NH:7][CH:4]2[CH2:5][CH2:6][O:1][CH2:2][CH2:3]2)=[O:14])=[C:11]([CH3:18])[CH:10]=1

Participants

3

Reactant 2

HCID 995704-Bromo-2-methylbenzoic acidHCID 4192234-Aminotetrahydropyran

Product 1

HCID 67479574HCID 67479574, compoundYield 100%

Procedure

The title compound was prepared in substantially the same way as intermediate (iv) by coupling of tetrahydropyran-4-yl amine with 4-bromo-2-methylbenzoic acid to give 0.65 g (100% yield) as a thick oil which solidified on standing.

Workup

  1. customto give 0.65 g (100% yield) as a thick oil which

Sources & evidence

ORD record
ord-d470fd7dd6a34bf78b581e473616ff81
Source dataset
uspto-grants-2014_06
Patent number
US08754095B2

Reaction notes

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