Hydrochloric Acid → Hydrochloric Acid

HRID 406126Notes

Reaction equation

HRID 406126 reaction equation
C([O:5][C:6](=[O:24])[C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH2:17][CH2:16][C@H:15]([N:18]3[CH2:22][CH2:21][CH2:20][C@@H:19]3[CH3:23])[CH2:14]2)=[CH:9][CH:8]=1)(C)(C)C.[ClH:25]>O1CCOCC1>[ClH:25].[CH3:23][C@H:19]1[CH2:20][CH2:21][CH2:22][N:18]1[C@H:15]1[CH2:16][CH2:17][N:13]([C:10]2[CH:11]=[CH:12][C:7]([C:6]([OH:24])=[O:5])=[CH:8][CH:9]=2)[CH2:14]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68211704HCID 68211704, compound

Product 2

HCID 313Hydrochloric AcidHCID 682114314-((25,3'S)-2-Methyl-[1,3']bipyrrolidinyl-1'-yl)-benzoic acid

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

4-((2S,3′S)-2-Methyl-[1,3′]bipyrrolidinyl-1′-yl)-benzoic acid tert-butyl ester (0.28 g, 0.8 mmol) was treated with 5 mL of 4N HCl in dioxane at r.t. overnight. The HCl was removed by air blowing and absorbed into NaOH aq. solution. The solvent was evaporated to dryness and dried further under high vacuum to yield 0.37 g (HCl salt, ˜100%) of the title compound as a white powder.

Workup

  1. customThe HCl was removed by air
  2. customabsorbed into NaOH aq. solution
  3. customThe solvent was evaporated to dryness
  4. customdried further under high vacuum

Sources & evidence

ORD record
ord-9771ac47bb744dba8fd35ec179d3de1c
Source dataset
uspto-grants-2014_06
Patent number
US08754095B2

Reaction notes

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