Lithium Hydroxide → HCID 66666360, compound

HRID 406205Notes

Reaction equation

HRID 406205 reaction equation
C([O:4][C@@H:5]1[C:14]2[C:9](=[N:10][C:11]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[N:13]=2)[N:8]([CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][C:33]([O:35]CC)=[O:34])[CH2:7][CH2:6]1)(=O)C.[Li+].[OH-]>>[OH:4][C@@H:5]1[C:14]2[C:9](=[N:10][C:11]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)=[C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[N:13]=2)[N:8]([CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][C:33]([OH:35])=[O:34])[CH2:7][CH2:6]1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 86681848HCID 86681848, compound

Product 1

HCID 66666360HCID 66666360, compound

Procedure

The title compound was prepared from (S)-ethyl 7-(8-acetoxy-2,3-diphenyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoate (step 1) and LiOH analogously to Example 9.1;

Sources & evidence

ORD record
ord-76917e64b28c4ae48ffd8528516a75c0
Source dataset
uspto-grants-2014_06
Patent number
US08754085B2

Reaction notes

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