Sodium Hydroxide → HCID 66666096, compound

HRID 406218Notes

Reaction equation

HRID 406218 reaction equation
[C:1]1([C:7]2[N:12]=[C:11]3[CH2:13][CH2:14][CH2:15][N:16]([CH2:17][C:18]4[CH:19]=[C:20]([CH:28]=[CH:29][CH:30]=4)[O:21][CH2:22][C:23]([O:25]CC)=[O:24])[C:10]3=[N:9][C:8]=2[C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>CCO>[C:1]1([C:7]2[N:12]=[C:11]3[CH2:13][CH2:14][CH2:15][N:16]([CH2:17][C:18]4[CH:19]=[C:20]([CH:28]=[CH:29][CH:30]=4)[O:21][CH2:22][C:23]([OH:25])=[O:24])[C:10]3=[N:9][C:8]=2[C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66665337HCID 66665337, compound

Product 1

HCID 66666096HCID 66666096, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 2-(34(2,3-diphenyl-7,8-dihydropyrido[3,2-b]pyrazin-5(6H)-yl)methyl)phenoxy)acetate (step 2) (163 mg, 0.340 mmol) in EtOH (2 ml) was treated dropwise with 2M NaOH (0.340 ml, 0.680 mmol). The solution was stirred at room temperature for 1 h. The resulting white suspension was collected by filtration, washed with water and dried in a vacuum oven at 40° C. to afford the title compound;

Workup

  1. filtrationThe resulting white suspension was collected by filtration
  2. washwashed with water
  3. customdried in a vacuum oven at 40° C.

Sources & evidence

ORD record
ord-dd380506105b4fc0a5bd25f4ce041e99
Source dataset
uspto-grants-2014_06
Patent number
US08754085B2

Reaction notes

Loading…