Hydrochloric Acid → HCID 66666541, compound

HRID 406236Notes

Reaction equation

HRID 406236 reaction equation
[C:1]1([CH3:36])[CH:6]=[CH:5][C:4]([C:7]2[N:8]=[C:9]3[CH2:23][CH2:22][CH2:21][N:20]([CH2:24][CH2:25][CH2:26][CH:27]([OH:35])[CH:28]([OH:34])[CH2:29][C:30]([O:32]C)=[O:31])[C:10]3=[N:11][C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=2)=[CH:3][CH:2]=1.[OH-].[Na+].Cl>CO>[C:1]1([CH3:36])[CH:2]=[CH:3][C:4]([C:7]2[N:8]=[C:9]3[CH2:23][CH2:22][CH2:21][N:20]([CH2:24][CH2:25][CH2:26][CH:27]([OH:35])[CH:28]([OH:34])[CH2:29][C:30]([OH:32])=[O:31])[C:10]3=[N:11][C:12]=2[C:13]2[CH:14]=[CH:15][C:16]([CH3:19])=[CH:17][CH:18]=2)=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 131731627HCID 131731627, compound

Product 1

HCID 66666541HCID 66666541, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To rac-Methyl 7-(2,3-dip-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)-3,4-dihydroxyheptanoate (Step 2) (30 mg, 0.061 mmol) in methanol (1 ml) was added 2M NaOH (0.061 ml, 0.123 mmol). The solution was stirred at room temperature for 3 h. 2M HCl (0.061 ml) was added and the solution was evaporated to dryness. The crude product was purified by chromatography on silica eluting with 0-15% DCM/MeOH to afford the title compound;

Workup

  1. customthe solution was evaporated to dryness
  2. customThe crude product was purified by chromatography on silica eluting with 0-15% DCM/MeOH

Sources & evidence

ORD record
ord-25f7e841215944fe90c29a2bd637537f
Source dataset
uspto-grants-2014_06
Patent number
US08754085B2

Reaction notes

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