Diethyl Ether → Z-(1S,6S)-7-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-ene

HRID 40625Notes

Reaction equation

[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[N:11]1[C:18](=O)[C@H:17]2[NH:20][C:21](=O)[C@@H:12]1[CH2:13][CH:14]=[CH:15][CH2:16]2.C1COCC1.C(OCC)C>O>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[N:11]1[CH2:18][C@H:17]2[NH:20][CH2:21][C@@H:12]1[CH2:13][CH:14]=[CH:15][CH2:16]2

Participants

Conditions

Temperature: 120 °C

Procedure

Z-(1S,6S)-7-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-ene-8,10-dione (0.8 g, 2.74 mmol) was dissolved in a solution of Dibal (THF, 1 M, 28 mL). The reaction was carried out in a large scale CEM microwave reaction vessel. The reaction mixture was heated to 120° C. for 0.5 h and then allowed to cool to room temperature. A one-liter Erlenmeyer flask was charged with diethyl ether (400 mL) and the reaction mixture was poured into the diethyl ether. A water solution of saturated Rochelle salts was added dropwise until gas stopped evolving and then water saturated with Rochelle salts (approximately 200 mL) was poured into the reaction mixture. The resulting mixture was stirred at room temperature until both phases were clear. The reaction mixture then was poured into a separatory funnel and the aqueous layer was discarded. The diethyl ether was dried with anhydrous magnesium sulfate and the solvent was removed using reduced pressure to yield a clear colorless oil.

Workup

customThe reaction was carried out in a large scale CEM microwave reaction vessel
temperatureto cool to room temperature
additionThe reaction mixture then was poured into a separatory funnel
dry with materialThe diethyl ether was dried with anhydrous magnesium sulfate
customthe solvent was removed
customto yield a clear colorless oil

Sources & evidence

ORD record: ord-42c13cec29574e0ea1c7dfdb3a57f4c9
Source dataset: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08530475B2

Reaction notes

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