1,2-Bis(4-methylphenyl)-1,2-ethanedione → 7-Chloro-2,3-dip-tolylpyrido[2,3-b]pyrazine

HRID 406268Notes

Reaction equation

HRID 406268 reaction equation
[C:1]1([CH3:18])[CH:6]=[CH:5][C:4]([C:7](=O)[C:8]([C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=2)=O)=[CH:3][CH:2]=1.[Cl:19][C:20]1[CH:21]=[C:22]([NH2:27])[C:23]([NH2:26])=[N:24][CH:25]=1.C1(C2N=C3CCCN(CCC/C=C/CC(O)=O)C3=NC=2C2C=CC=CC=2)C=CC=CC=1>C(O)(=O)C>[Cl:19][C:20]1[CH:25]=[N:24][C:23]2=[N:26][C:8]([C:10]3[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=3)=[C:7]([C:4]3[CH:5]=[CH:6][C:1]([CH3:18])=[CH:2][CH:3]=3)[N:27]=[C:22]2[CH:21]=1

Participants

5

Reactant 3

HCID 769961,2-Bis(4-methylphenyl)-1,2-ethanedioneHCID 12682545-Chloropyridine-2,3-diamineHCID 66665765(E)-7-(2,3-Diphenyl-7,8-dihydropyrido[3,2-b]pyrazin-5(6H)-yl)hept-3-enoic acid

Product 1

HCID 666663497-Chloro-2,3-dip-tolylpyrido[2,3-b]pyrazine

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The title compound was prepared from 1,2-dip-tolylethane-1,2-dione and 5-chloro-pyridine-2,3-diamine analogously to 2,3-dip-tolylpyrido[2,3-b]pyrazine (Intermediate E step 1). Acetic acid is not used in this reaction.

Sources & evidence

ORD record
ord-4f258bbbcb2b41c89c6374e8bbe07a28
Source dataset
uspto-grants-2014_06
Patent number
US08754085B2

Reaction notes

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