Diisobutylaluminum hydride → Z-(1R,6R)-7-naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-ene

Participants

Reaction Conditions

Reaction Steps

7-Naphthalen-2-yl-7,9-diaza-bicyclo[4.2.2]dec-3-ene-8,10-dione (130 mg, 0.45 mmol) and DiBAl-H (6 mL, 1M, 6 mmol) were placed in a μW tube under argon vent. The reaction mixture was then heated to 130° C. for 900 sec. The reaction was quenched with Rochelle's salt and diethyl ether mixture (1:1, 200 mL) and then stirred overnight. The organic eas layer separated and dried with magnesium sulfate, filtered and solvent evaporated under reduced pressure to yield the title compound as a residue.

Provenance & Evidence