Hydrochloric Acid → HCID 178479289, compound

Participants

Reaction Steps

To 1,1-dimethylethyl {trans-3-[(2,3-dichlorophenyl)oxy]cyclobutyl}carbamate (10.78 g, 17.85 mmol) was added 4M hydrochloric acid in dioxane (150 mL, 600 mmol) and the reaction mixture stirred in a sealed vessel at room temperature for 18 hours. The mixture was then diluted with diethyl ether (300 mL), stirred for 10 min and then filtered and the solid dried in vacuo to give the title compound (4.4096 g).

Provenance & Evidence