Hydrochloric Acid → HCID 178479289, compound

HRID 406282Notes

Reaction equation

HRID 406282 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[O:9][C@H:10]1[CH2:13][C@H:12]([NH:14]C(=O)OC(C)(C)C)[CH2:11]1.Cl.O1CCOCC1>C(OCC)C>[ClH:1].[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[O:9][C@H:10]1[CH2:11][C@H:12]([NH2:14])[CH2:13]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 178454128HCID 178454128, compound

Product 1

HCID 178479289HCID 178479289, compoundYield 184%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To 1,1-dimethylethyl {trans-3-[(2,3-dichlorophenyl)oxy]cyclobutyl}carbamate (10.78 g, 17.85 mmol) was added 4M hydrochloric acid in dioxane (150 mL, 600 mmol) and the reaction mixture stirred in a sealed vessel at room temperature for 18 hours. The mixture was then diluted with diethyl ether (300 mL), stirred for 10 min and then filtered and the solid dried in vacuo to give the title compound (4.4096 g).

Workup

  1. stirringstirred for 10 min
  2. filtrationfiltered
  3. customthe solid dried in vacuo

Sources & evidence

ORD record
ord-001411bb4215410888f9de573ed15537
Source dataset
uspto-grants-2014_06
Patent number
US08754101B2

Reaction notes

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