Hydrazine hydrate (1:1) → HCID 21803236, compound

HRID 406317Notes

Reaction equation

HRID 406317 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][C:10](=O)[O:11]C1C=CC=CC=1.O.[NH2:22][NH2:23]>C(O)C>[F:1][C:2]([F:20])([F:19])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][C:10]([NH:22][NH2:23])=[O:11]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 681880HCID 681880, compound

Product 1

HCID 21803236HCID 21803236, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Phenyl (2-trifluoromethylphenyl)carbamate (12.1 g) was dissolved in ethanol (150 mL). Hydrazine monohydrate (16.7 mL) was added and the mixture was heated under reflux for 2.25 hours. The reaction solution was concentrated under reduced pressure and the residue was purified by silica gel column chromatography to obtain the title compound (7.5 g).

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 2.25 hours
  3. concentrationThe reaction solution was concentrated under reduced pressure
  4. customthe residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-7fe6cf35040649cb9586b7d45e33b817
Source dataset
uspto-grants-2014_06
Patent number
US08754100B2

Reaction notes

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