Hydrazine hydrate (1:1) → HCID 66618909, compound

HRID 406336Notes

Reaction equation

HRID 406336 reaction equation
[O:1]1[CH2:3][CH:2]1[CH2:4][CH:5]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]([F:19])([F:18])[F:17])[C:6](OC)=[O:7].O.[NH2:21][NH2:22]>C(O)C>[NH2:21][N:22]1[CH2:3][CH:2]([OH:1])[CH2:4][CH:5]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[C:16]([F:19])([F:18])[F:17])[C:6]1=[O:7]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 86662651HCID 86662651, compound

Product 1

HCID 66618909HCID 66618909, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methyl 3-oxiranyl-2-(2-trifluoromethylphenyl)propionate (2.61 g) was dissolved in ethanol (20 mL). Hydrazine monohydrate (2.3 mL) was added at room temperature, and the mixture was reacted for 24 hours. Concentration under reduced pressure gave an oil which was partitioned with methylene chloride and water. The aqueous layer was extracted with methylene chloride four times. After drying over magnesium sulfate, concentration under reduced pressure gave the title compound (1.8 g) as a pale yellow solid.

Workup

  1. customthe mixture was reacted for 24 hours
  2. concentrationConcentration under reduced pressure
  3. customgave an oil which
  4. customwas partitioned with methylene chloride and water
  5. extractionThe aqueous layer was extracted with methylene chloride four times
  6. dry with materialAfter drying over magnesium sulfate, concentration under reduced pressure

Sources & evidence

ORD record
ord-58410205be2340e9895362d5397279a8
Source dataset
uspto-grants-2014_06
Patent number
US08754100B2

Reaction notes

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