Trifluoroacetic acid → HCID 66618912, compound

HRID 406344Notes

Reaction equation

HRID 406344 reaction equation
[O:1]=[C:2]1[CH2:7][CH2:6][CH2:5][CH:4]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[N:3]1[NH:18]C(=O)OC(C)(C)C.FC(F)(F)C(O)=O>C(Cl)(Cl)Cl>[NH2:18][N:3]1[CH:4]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:15])([F:16])[F:17])[CH:9]=2)[CH2:5][CH2:6][CH2:7][C:2]1=[O:1]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86662652HCID 86662652, compound

Product 1

HCID 66618912HCID 66618912, compoundYield 78.6%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

tert-Butyl [2-oxo-6-(3-trifluoromethylphenyl)piperidin-1-yl]carbamate (210 mg) was dissolved in chloroform (4 mL), followed by addition of trifluoroacetic acid (2 mL). After stirring at room temperature for four hours, concentration under reduced pressure gave the title compound (119 mg). The property values of the compound are as follows.

Workup

  1. concentrationconcentration under reduced pressure

Sources & evidence

ORD record
ord-88d2f65a0c944ce59ea27b472c475bfa
Source dataset
uspto-grants-2014_06
Patent number
US08754100B2

Reaction notes

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