Ammonia methanol → 4-Carbamoyl-3-(2-trifluoromethylphenyl)butanoic acid

HRID 406377Notes

Reaction equation

HRID 406377 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]1[CH2:14][C:13](=[O:15])[O:12][C:11](=[O:16])[CH2:10]1.[NH3:19].CO>>[C:11]([CH2:10][CH:9]([C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:2]([F:18])([F:17])[F:1])[CH2:14][C:13]([OH:12])=[O:15])(=[O:16])[NH2:19]

Participants

3

Reactant 2

HCID 21705897Ammonia methanolHCID 866626534-[2-(Trifluoromethyl)phenyl]oxane-2,6-dione

Product 1

HCID 666189254-Carbamoyl-3-(2-trifluoromethylphenyl)butanoic acid

Procedure

Saturated ammonia/methanol (10 mL) was added to 4-(2-trifluoromethylphenyl)dihydropyrane-2,6-dione (636 mg), and the mixture was stirred at room temperature for 15 hours. Concentration under reduced pressure gave a crude product (716 mg) which was used for the next reaction without purification.

Workup

  1. concentrationConcentration under reduced pressure

Sources & evidence

ORD record
ord-51d076da9ddd406d83e6d756beb2d863
Source dataset
uspto-grants-2014_06
Patent number
US08754100B2

Reaction notes

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