HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia methanol → 4-Carbamoyl-3-(2-trifluoromethylphenyl)butanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia methanol | HCID 21705897 | — |
| Reactant | 4-[2-(Trifluoromethyl)phenyl]oxane-2,6-dione | HCID 86662653 | — |
| Product | 4-Carbamoyl-3-(2-trifluoromethylphenyl)butanoic acid | HCID 66618925 | — |
Reaction Steps
Saturated ammonia/methanol (10 mL) was added to 4-(2-trifluoromethylphenyl)dihydropyrane-2,6-dione (636 mg), and the mixture was stirred at room temperature for 15 hours. Concentration under reduced pressure gave a crude product (716 mg) which was used for the next reaction without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08754100B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-51d076da9ddd406d83e6d756beb2d863 |
| Source note | uspto-grants-2014_06 |