Water → HCID 66618818, compound

Participants

Reaction Steps

To a solution of 1,1,1-trifluoro-2-(4-methoxy-3-methylphenyl)-propane-2-ol (1 g) in DMF (20 ml) were added sodium hydride (60% in mineral oil, 205 mg) and iodomethane (727 mg). After stirring for 5 hours at room temperature, the reaction mixture was ice cooled, then water and ethyl acetate were added to the reaction mixture. The organic layer was separated and washed with brine, and dried over anhydrous magnesium sulfate. After removing the drying agent, the organic layer was concentrated under reduced pressure.

Provenance & Evidence