Water → HCID 66618818, compound

HRID 406387Notes

Reaction equation

HRID 406387 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]([C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([CH3:14])[CH:7]=1)([OH:5])[CH3:4].[H-].[Na+].I[CH3:20].O>CN(C=O)C.C(OCC)(=O)C>[CH3:13][O:12][C:9]1[CH:10]=[CH:11][C:6]([C:3]([O:5][CH3:20])([CH3:4])[C:2]([F:15])([F:16])[F:1])=[CH:7][C:8]=1[CH3:14]

Participants

7

Reactant 4

HCID 962WaterHCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 66618813HCID 66618813, compound

Product 1

HCID 66618818HCID 66618818, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 1,1,1-trifluoro-2-(4-methoxy-3-methylphenyl)-propane-2-ol (1 g) in DMF (20 ml) were added sodium hydride (60% in mineral oil, 205 mg) and iodomethane (727 mg). After stirring for 5 hours at room temperature, the reaction mixture was ice cooled, then water and ethyl acetate were added to the reaction mixture. The organic layer was separated and washed with brine, and dried over anhydrous magnesium sulfate. After removing the drying agent, the organic layer was concentrated under reduced pressure.

Workup

  1. temperaturecooled
  2. customThe organic layer was separated
  3. washwashed with brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customAfter removing the drying agent
  6. concentrationthe organic layer was concentrated under reduced pressure

Sources & evidence

ORD record
ord-7f68185f8e8f448cb7964dbc615eaff1
Source dataset
uspto-grants-2014_06
Patent number
US08754100B2

Reaction notes

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