Methyl iodide → 1-Benzyl-1-methyl-4-oxopiperidinium iodide

HRID 406389Notes

Reaction equation

HRID 406389 reaction equation
[I:1][CH3:2].[CH2:3]([N:10]1[CH2:15][CH2:14][C:13](=[O:16])[CH2:12][CH2:11]1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>CC(C)=O>[I-:1].[CH2:3]([N+:10]1([CH3:2])[CH2:15][CH2:14][C:13](=[O:16])[CH2:12][CH2:11]1)[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 192201-Benzyl-4-piperidone

Product 1

HCID 110780641-Benzyl-1-methyl-4-oxopiperidinium iodide

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Iodomethane (20.2 ml) was added to a solution of 1-benzyl-4-piperidone (50 ml) in acetone (300 ml) and the mixture was stirred at room temperature overnight. The deposited crystals were collected and washed with acetone to obtain a title compound (77.1 g).

Workup

  1. customThe deposited crystals were collected
  2. washwashed with acetone

Sources & evidence

ORD record
ord-82209429d3b645338d2f863ffa990e06
Source dataset
uspto-grants-2014_06
Patent number
US08754100B2

Reaction notes

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