Benzamide → HCID 178487741, compound

HRID 406409Notes

Reaction equation

[NH2:1][C:2]1[C:10]([CH3:11])=[C:9]([O:12][CH3:13])[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].C(N)(=O)C1C=CC=CC=1.Cl.[C:24](Cl)(=O)[C:25]1[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=1>>[CH3:13][O:12][C:9]1[C:10]([CH3:11])=[C:2]2[C:3]([C:4]([OH:5])=[N:6][C:24]([C:25]3[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=3)=[N:1]2)=[CH:7][CH:8]=1

Participants

Reactant 3

HCID 2331Benzamide

HCID 12262826Isonicotinoyl chloride hydrochloride

HCID 591654352-Amino-4-methoxy-3-methylbenzamide

Product 1

HCID 178487741HCID 178487741, compoundYield 60%

Procedure

The general procedure described in Example 10 was followed using 2-amino-4-methoxy-3-methyl benzamide as benzamide derivative and isonicotinoyl chloride hydrochloride as acid chloride, which gave the title compound (1.6 g, 60%), [M+H]=268.

Sources & evidence

ORD record: ord-956087dcced240b482c62bdb20a0189a
Source dataset: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08754105B2

Reaction notes

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