Benzamide → HCID 178487740, compound

HRID 406413Notes

Reaction equation

HRID 406413 reaction equation
[NH2:1][C:2]1[C:10]([CH3:11])=[C:9]([O:12][CH3:13])[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].C(N)(=O)C1C=CC=CC=1.[F:23][C:24]1[CH:25]=[C:26]([CH:30]=[C:31]([F:33])[CH:32]=1)[C:27](Cl)=O>>[F:23][C:24]1[CH:25]=[C:26]([C:27]2[N:6]=[C:4]([OH:5])[C:3]3[C:2](=[C:10]([CH3:11])[C:9]([O:12][CH3:13])=[CH:8][CH:7]=3)[N:1]=2)[CH:30]=[C:31]([F:33])[CH:32]=1

Participants

4

Reactant 3

HCID 2331BenzamideHCID 1456003,5-Difluorobenzoyl chlorideHCID 591654352-Amino-4-methoxy-3-methylbenzamide

Product 1

HCID 178487740HCID 178487740, compoundYield 85%

Procedure

The general procedure described in Example 10 was followed using 2-amino-4-methoxy-3-methyl benzamide as benzamide derivative [A] and 3,5-difluoro-benzoyl chloride as acid chloride [B], which gave the title compound (2.1 g, 85%), [M+H]=303.

Sources & evidence

ORD record
ord-acadc822c3a04807bba75b0511f2452d
Source dataset
uspto-grants-2014_06
Patent number
US08754105B2

Reaction notes

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