反应详情

To a round bottom flask was added 3,6-dichloropyridazine (20.1 mmole), 4-(methylsulfonylamino)phenylboronic acid (20.1 mmole), tetrakis(triphenylphosphine)palladium (1.00 mmole), 2M Na2CO3 (30 mL), and 1,2-dimethoxyethane (120 mL). The resulting reaction mixture was heated at 85 C for 22 hours. The reaction mixture was diluted with ethyl acetate and filtered through celite. The filtrate was washed with water. The organic extract was dried over Na2SO4 and evaporated in vacuo. The crude residue was purified by biotage column chromatography eluting with 4:1 ethyl acetate to hexane mixture to afford N-(4-(6-chloropyridazin-3-yl)phenyl)methanesulfonamide.

1. customThe resulting reaction mixture
2. temperaturewas heated at 85 C for 22 hours
3. filtrationfiltered through celite
4. washThe filtrate was washed with water
5. extractionThe organic extract
6. dry with materialwas dried over Na2SO4
7. customevaporated in vacuo
8. customThe crude residue was purified by biotage column chromatography
9. washeluting with 4:1 ethyl acetate to hexane mixture