Hydrazine hydrate (1:1) → HCID 58118989, compound

HRID 406431Notes

Reaction equation

HRID 406431 reaction equation
[CH2:1]([O:8][CH2:9][C:10]1[C:15]([Cl:16])=[CH:14][CH:13]=[C:12](Cl)[N:11]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.[NH2:19][NH2:20]>>[CH2:1]([O:8][CH2:9][C:10]1[C:15]([Cl:16])=[CH:14][CH:13]=[C:12]([NH:19][NH2:20])[N:11]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 55127404HCID 55127404, compound

Product 1

HCID 58118989HCID 58118989, compound

Conditions

Temperature
120 °C

Procedure

A sealable flask is charged with 2-(benzyloxymethyl)-3,6-dichloropyridine as prepated in Step 2 (950 mg, 3.5 mmol), hydrazine hydrate (1 mL) is added, and the reaction is heated to 120° C. overnight. After cooling the solids are collected by filtration to provide 2-(benzyloxymethyl)-3-chloro-6-hydrazinylpyridine.

Workup

  1. additionis added
  2. temperatureAfter cooling the solids
  3. filtrationare collected by filtration

Sources & evidence

ORD record
ord-15afd440509c4f82b7d6d097945a3edd
Source dataset
uspto-grants-2014_06
Patent number
US08754103B2

Reaction notes

Loading…