Acetic Anhydride → HCID 66849330, compound

HRID 406434Notes

Reaction equation

HRID 406434 reaction equation
[CH:1]([C:4]1[N:8]2[CH:9]=[C:10]([C:14]3[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=3)[CH:11]=[C:12]([NH2:13])[C:7]2=[N:6][N:5]=1)([CH3:3])[CH3:2].[C:25](OC(=O)C)(=[O:27])[CH3:26].C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH:1]([C:4]1[N:8]2[CH:9]=[C:10]([C:14]3[CH:15]=[CH:16][C:17]([O:20][C:21]([F:23])([F:22])[F:24])=[CH:18][CH:19]=3)[CH:11]=[C:12]([NH:13][C:25](=[O:27])[CH3:26])[C:7]2=[N:6][N:5]=1)([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 66849121HCID 66849121, compound

Product 1

HCID 66849330HCID 66849330, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

In a heavy-wall pressure tube was added 3-isopropyl-6-(4-(trifluoromethoxy)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-8-amine prepared in 9A in toluene. To this suspension was added the acetic anhydride (0.1 mL) followed my triethylamine (0.1 mL). The mixture was heated in a 110 C oil bath for 12 hours. The reaction mixture was evaporated in vacuo and purified by preparative HPLC to afford N-(3-isopropyl-6-(4-(trifluoromethoxy)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-8-yl)acetamide.

Workup

  1. temperatureThe mixture was heated in a 110 C oil bath for 12 hours
  2. customThe reaction mixture was evaporated in vacuo
  3. custompurified by preparative HPLC

Sources & evidence

ORD record
ord-f231fc95114447ec81a365bdb474c6fc
Source dataset
uspto-grants-2014_06
Patent number
US08754103B2

Reaction notes

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