Tetrahydro-4H-pyran-4-one → HCID 24988507, compound

HRID 406508Notes

Reaction equation

HRID 406508 reaction equation
[NH2:1][C@@H:2]1[CH2:6][CH2:5][N:4]([C:7](=[O:22])[CH2:8][NH:9][C:10]2[C:19]3[C:14](=[CH:15][C:16]([Cl:21])=[C:17]([Cl:20])[CH:18]=3)[N:13]=[CH:12][N:11]=2)[C@H:3]1[CH3:23].[O:24]1[CH2:29][CH2:28][C:27](=O)[CH2:26][CH2:25]1>>[Cl:20][C:17]1[CH:18]=[C:19]2[C:14](=[CH:15][C:16]=1[Cl:21])[N:13]=[CH:12][N:11]=[C:10]2[NH:9][CH2:8][C:7]([N:4]1[CH2:5][CH2:6][C@@H:2]([NH:1][CH:27]2[CH2:28][CH2:29][O:24][CH2:25][CH2:26]2)[C@@H:3]1[CH3:23])=[O:22]

Participants

3

Reactant 2

HCID 121599Tetrahydro-4H-pyran-4-oneHCID 69228856HCID 69228856, compound

Product 1

HCID 24988507HCID 24988507, compound

Procedure

2-(6,7-Dichloroquinazolin-4-ylamino)-1-((2S,3R)-2-methyl-3-(tetrahydro-2H-pyran-4-ylamino)pyrrolidin-1-yl)ethanone was synthesized from 1-((2S,3R)-3-Amino-2-methylpyrrolidin-1-yl)-2-(6,7-dichloroquinazolin-4-ylamino)ethanone and dihydro-2H-pyran-4(3H)-one using general procedure E. RP-HPLC (Table 1, Method a) Rt 1.52; m/z: (M+H)+ 438.

Sources & evidence

ORD record
ord-6d5ff092d8e046de882a2091f272a947
Source dataset
uspto-grants-2014_06
Patent number
US08754107B2

Reaction notes

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