Methyl iodide → 4-Bromo-5,6-dimethylpyridin-2-ol

HRID 406732Notes

Reaction equation

HRID 406732 reaction equation
[Br:1][C:2]1[C:7]([CH3:8])=[C:6]([CH3:9])[NH:5][C:4](=[O:10])[CH:3]=1.CI.[C:13]([O-])([O-])=O.[K+].[K+]>>[Br:1][C:2]1[C:7]([CH3:8])=[C:6]([CH3:9])[N:5]([CH3:13])[C:4](=[O:10])[CH:3]=1.[Br:1][C:2]1[C:7]([CH3:8])=[C:6]([CH3:9])[NH:5][C:4](=[O:10])[CH:3]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 469162514-Bromo-5,6-dimethylpyridin-2-ol

Product 2

HCID 469162514-Bromo-5,6-dimethylpyridin-2-olHCID 66736202HCID 66736202, compound

Procedure

4-bromo-1,5,6-trimethylpyridin-2(1H)-one was prepared by alkylation of 4-bromo-5,6-dimethylpyridin-2(1H)-one with methyl iodide using K2CO3 following a procedure analogous to that described in Example 59 Step 1. 4-bromo-5,6-dimethylpyridin-2(1H)-one was prepared following the procedure described in McElroy, W. T. and DeShong, P. Org. Lett. 2003, 5, 4779.

Sources & evidence

ORD record
ord-37bc02be0abe4de28f0f8f2bf2be5648
Source dataset
uspto-grants-2014_06
Patent number
US08754076B2

Reaction notes

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