Trifluoroacetic acid → HCID 59635643, compound

HRID 406733Notes

Reaction equation

HRID 406733 reaction equation
FC(F)(F)C(O)=O.[CH:8]1([N:11]2[CH:16]=[CH:15][C:14]([O:17]CC3C=CC(OC)=CC=3)=[CH:13][C:12]2=[O:27])[CH2:10][CH2:9]1>>[CH:8]1([N:11]2[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][C:12]2=[O:27])[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 596358071-Cyclopropyl-4-(4-methoxy-benzyloxy)-1H-pyridin-2-one

Product 1

HCID 59635643HCID 59635643, compound

Procedure

Trifluoroacetic acid (1 mL) was added to a flask charged with a stir bar and 1-cyclopropyl-4-(4-methoxy-benzyloxy)-1H-pyridin-2-one (0.17 g) and chilled in an ice/EtOH bath. The resulting mixture was stirred with cooling for 1.5 h and at ambient temperature for another 4.5 h. Then, the solution was concentrated under reduced pressure and the residue was triturated with tert-butyl methyl ether and dried to give the title compound as a solid. Yield: 0.10 g (quantitative). Mass spectrum (ESI+): m/z=152 [M+H]+.

Workup

  1. additioncharged with a stir bar
  2. concentrationThen, the solution was concentrated under reduced pressure
  3. customthe residue was triturated with tert-butyl methyl ether
  4. customdried

Sources & evidence

ORD record
ord-47439e4e41784e70961d09ea4ea0f993
Source dataset
uspto-grants-2014_06
Patent number
US08754076B2

Reaction notes

Loading…