5-Bromo-1-methylpyridin-2(1H)-one → HCID 59635704, compound

HRID 406740Notes

Reaction equation

HRID 406740 reaction equation
[CH3:1][O:2][CH2:3][C@@:4]1([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[O:9][C:8](=[O:10])[N:7]([C@H:11]([C:13]2[CH:18]=[CH:17][C:16](B3OC(C)(C)C(C)(C)O3)=[CH:15][CH:14]=2)[CH3:12])[CH2:6][CH2:5]1.Br[C:35]1[CH:36]=[CH:37][C:38](=[O:42])[N:39]([CH3:41])[CH:40]=1>>[CH3:1][O:2][CH2:3][C@@:4]1([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[O:9][C:8](=[O:10])[N:7]([C@H:11]([C:13]2[CH:18]=[CH:17][C:16]([C:35]3[CH:36]=[CH:37][C:38](=[O:42])[N:39]([CH3:41])[CH:40]=3)=[CH:15][CH:14]=2)[CH3:12])[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 130240275-Bromo-1-methylpyridin-2(1H)-oneHCID 58109551HCID 58109551, compound

Product 1

HCID 59635704HCID 59635704, compound

Procedure

The title compound was prepared from (R)-6-(methoxymethyl)-6-phenyl-3-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)-1,3-oxazinan-2-one and 5-bromo-1-methylpyridin-2(1H)-one following a procedure analogous to that described in Example 76. Mass spectrum (ESI+): m/z=433 [M+H]+

Sources & evidence

ORD record
ord-407551e38a4a4cfabfd3dc8c0e44a3e6
Source dataset
uspto-grants-2014_06
Patent number
US08754076B2

Reaction notes

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