6-cyclopropyl-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-1,3-oxazinan-2-one → (R)-2-methyl-propane-2-sulfinic acid [(S)-1-(4-bromo-3-methyl-phenyl)-ethyl]amide

HRID 406774Notes

Reaction equation

HRID 406774 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[N:10][S@@:11]([C:13]([CH3:16])([CH3:15])[CH3:14])=[O:12])[CH3:9])=[CH:4][C:3]=1[CH3:17].C1(C2(CC(O)(C)C)OC(=O)N([C@H](C3C=CC(C4C=CN(C)C(=O)C=4)=CC=3)C)CC2)CC1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([NH:10][S@@:11]([C:13]([CH3:16])([CH3:15])[CH3:14])=[O:12])[CH3:9])=[CH:4][C:3]=1[CH3:17]

Participants

3

Reactant 2

HCID 596356736-cyclopropyl-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-1,3-oxazinan-2-oneHCID 86649415(R)-2-methyl-propane-2-sulfinic acid [1-(4-bromo-3-methyl-phenyl)ethylidene]-amide

Product 1

HCID 58102400(R)-2-methyl-propane-2-sulfinic acid [(S)-1-(4-bromo-3-methyl-phenyl)-ethyl]amide

Procedure

The title compound was prepared from (R)-2-methyl-propane-2-sulfinic acid [1-(4-bromo-3-methyl-phenyl)-ethylidene]-amide following a procedure analogous to that described in Step 2 of Intermediate 1. LC-MS (Method 5): tR=4.04 min; Mass spectrum (ESI+): m/z=318/320 (Br) [M+H]+.

Sources & evidence

ORD record
ord-e451468465004465882b71618067d020
Source dataset
uspto-grants-2014_06
Patent number
US08754076B2

Reaction notes

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